Principal Software Engineer

Company: The University of Chicago

Location: Chicago, IL 60637

Salary: $120,000 - $170,000 a year

Type: Full-time

Posted: 2026-03-30

About this role

Department

BSD CTD - Engineering - Plan X

About the Department

The Center for Translational Data Science (CTDS) at the University of Chicago is a research center whose mission is to develop the discipline of translational data science to impactful problems in biology, medicine, healthcare, and the environment. We envision a world in which researchers have ready access to the data needed and the tools required to make data driven discoveries that increase our scientific knowledge and improve the quality of life. We architect ecosystems of large-scale commons of research data, computing resources, applications, tools, and services for the broader research community to use data at scale to pursue scientific inquiry and accelerate discovery. Learn more at https://gdc.cancer.gov/, https://gen3.org/, https://stats.gen3.org/, and https://ctds.uchicago.edu/.

Job Summary

The job leads and provides expertise to the development of programs for activities relating to software support and/or development. Analyzes, designs, develops, debugs, and modifies computer code for end user applications, beta general releases, and production support. Manages development and implementation of applications, web pages, and user-interfaces using a variety of software applications, techniques, and tools. Solves complex problems in administration, maintenance, integration, and troubleshooting of code and application ecosystem currently in production.

The Principal Software Engineer is responsible for a scope of significant size or functional area critical to the team’s success, using in-depth knowledge in all technical areas of major projects and core product and responsible for design and implementation of top priority technical tasks, timely and quality delivery, leading and mentoring other engineers, and helping the organization drive toward its strategic goals, negotiating complex solutions along the way. All Software Engineers perform web application development activi...

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